<p>Autophagy Regulates the Stemness of Cervical Cancer Stem Cells [Retraction]</p>
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چکیده
منابع مشابه
Autophagy regulates the stemness of cervical cancer stem cells
Cancer stem cells (CSCs) are a rare population of multipotent cells with the capacity to self-renew. It has been reported that there are CSCs in cervical cancer cells. Pluripotency-associated (PA) transcription factors such as Oct4, Sox2, Nanog and CD44 have been used to isolate CSCs subpopulations. In this study, we showed that autophagy plays an important role in the biological behavior of ce...
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Cancer is one of the most important diseases of humans, for which no cure has been found so far. Understanding the causes of cancer can pave the way for its treatment. Alteration in genetic elements such as oncogenes and tumor suppressor genes results in cancer. The most recent theory for the origin of cancer has been provided by cancer stem cells (CSCs). Tumor-initiating cells (T-ICs) or CSCs ...
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Carcinogenesis and tumor cells had long been thought to be produced by genetic mutations, until the emergence of the cancer stem cell (CSC) model. This relatively new model reveals another layer of complexity in malignancy formation and maintenance. However, these hard-to-track subpopulations have not only been challenging to understand at the molecular level but have also prevented the develop...
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BACKGROUND Cervical cancer is the second most common cancer in females. Recent reports have revealed the critical role of cervical cancer stem cells (CSCs) in tumorigenicity and metastasis. Previously we demonstrated that A1E exerts an anti-proliferative action, which inhibits the growth of cervical cancer cells. METHODS A1E is composed of 11 oriental medicinal herbs. Cervical cancer cell cul...
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Human breast cancers include cancer stem cell populations as well as non-tumorigenic cancer cells. Breast cancer stem cells possess self-renewal capability and thus are the root cause of recurrence and metastasis of malignant tumors. Hypoxia is a fundamental pathological feature of solid tumor tissues and exerts a wide range of effects on the biological behavior of cancer cells. However, there ...
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ژورنال
عنوان ژورنال: Biologics: Targets and Therapy
سال: 2020
ISSN: 1177-5491
DOI: 10.2147/btt.s254584